Issue 37, 2019

Selective single C–F bond arylation of trifluoromethylalkene derivatives

Abstract

A strategically novel single C–F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

Graphical abstract: Selective single C–F bond arylation of trifluoromethylalkene derivatives

Supplementary files

Article information

Article type
Edge Article
Submitted
20 Apr 2019
Accepted
04 Aug 2019
First published
05 Aug 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 8701-8705

Selective single C–F bond arylation of trifluoromethylalkene derivatives

L. Tang, Z. Liu, W. She and C. Feng, Chem. Sci., 2019, 10, 8701 DOI: 10.1039/C9SC01966A

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