Issue 10, 1996

Simple enantiomeric excess determination of amines using chiral selones: unusual N–H⋯Se bonding detected by HMQC 1H/77Se NMR spectroscopy

Abstract

One-pot coupling of a chiral selone derivatizing agent to a series of chiral and racemic amines mediated with triphosgene gives adducts in yields ranging from 80–99%; 77Se NMR spectroscopy evaluation of the diastereoisomeric adduct conveniently allows the determination of the enantiomeric excesses of the parent chiral amines.

Article information

Article type
Paper

Chem. Commun., 1996, 1125-1126

Simple enantiomeric excess determination of amines using chiral selones: unusual N–H⋯Se bonding detected by HMQC 1H/77Se NMR spectroscopy

R. Wu, G. Hernández, J. D. Odom, R. B. Dunlap and L. A. Silks, Chem. Commun., 1996, 1125 DOI: 10.1039/CC9960001125

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