Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Zhiyong Liu; Mengsi Wu; Yudong Xue; Chao Chen; Frederik R. Wurm; Minbo Lan; Weian Zhang

doi:10.1039/D0CC00142B

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Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy†

Zhiyong Liu,^a Mengsi Wu,^a Yudong Xue,^a Chao Chen,

^b Frederik R. Wurm,

*^c Minbo Lan

^a and Weian Zhang

*^a

Author affiliations

* Corresponding authors

^a Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: wazhang@ecust.edu.cn

^b State Key Laboratory of Bioreactor Engineering Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

^c Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany
E-mail: wurm@mpip-mainz.mpg.de

Abstract

An entirely biodegradable nano-photosensitizer platform (PPE-FP₂) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP₂ avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

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Article information

DOI: https://doi.org/10.1039/D0CC00142B
Article type: Communication
Submitted: 07 Jan 2020
Accepted: 16 Jan 2020
First published: 17 Jan 2020
This article is Open Access

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Chem. Commun., 2020,56, 2415-2418

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Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Z. Liu, M. Wu, Y. Xue, C. Chen, F. R. Wurm, M. Lan and W. Zhang, Chem. Commun., 2020, 56, 2415 DOI: 10.1039/D0CC00142B

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Chemical Communications

Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy†

Abstract

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Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

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