Issue 81, 2020
From the journal:

Chemical Communications

Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response†

Ruidong Cheng,ab   Guo Li,a   Li Fan,*c   Jinqiang Jiang ORCID logo *a  and  Yue Zhao ORCID logo *b  

* Corresponding authors

a Key Laboratory of Syngas Conversion of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi Province, P. R. China
E-mail: jiangjq@snnu.edu.cn

b Departement de Chimie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
E-mail: yue.zhao@usherbrooke.ca

c Department of Pharmaceutical Chemistry and Analysis, School of Pharmacy, Fourth Military Medical University, Xi’an, Shaanxi Province, P. R. China
E-mail: xxfanny@fmmu.edu.cn

Abstract

Reactive oxygen species (ROS)-responsive prodrug nanoplatforms may not work efficiently due to insufficient ROS concentrations, so therapeutic polymersomes of a metallisable triamine-centered iminoboronate-functionalized amphiphilic starlike prodrug (N3-(OEG-IBCAPE)4) are prepared to show a Cu(II)-mediated Fenton reaction-enhanced ROS response.

Graphical abstract: Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response

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Article information

DOI
https://doi.org/10.1039/D0CC03607B
Article type
Communication
Submitted
21 May 2020
Accepted
02 Sep 2020
First published
02 Sep 2020

Chem. Commun., 2020,56, 12246-12249

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Therapeutic iminoboronate-based polymersomes with a Cu(II)-mediated Fenton reaction-enhanced ROS-response

R. Cheng, G. Li, L. Fan, J. Jiang and Y. Zhao, Chem. Commun., 2020, 56, 12246 DOI: 10.1039/D0CC03607B

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