Magnetic nanocatalysts utilized in the synthesis of aromatic pharmaceutical ingredients

Abstract

Here, we provide a brief survey of the recent advances in catalytic processes used in organic reactions, focusing on magnetic heterogeneous nanocatalysts (MHNCs). In the last decade, many magnetic nanocatalysts have been designed and applied to complex organic reaction procedures for the syntheses of active pharmaceutical ingredients (APIs). One of the most reported applications is the facilitation of multicomponent reactions (MCRs) by utilizing various composite structures. The high biodegradability and biocompatibility of MHNCs that comply with green chemistry principles greatly favor the use of these types of material. Moreover, MHNCs have been applied instead of complex and time-consuming purification procedures because they can be separated in a highly convenient process. There are also other advantages to the use of MHNCs such as convenient preparation routes (including low-cost raw materials), surface functionalization capability, and high structural stability. In this survey, we try to summarize recent progress in the field of MHNCs applicable to the synthesis of APIs such as biphenyl, pyrrole, benzyl azide derivatives, etc.