Tumor-targeted superfluorinated micellar probe for sensitive in vivo19F-MRI†
Lucie
Jamgotchian, 
‡a
Erwan
Selingue,
b
Agathe
Belime,
a
Guillaume
Pinna,
d
Wai Li
Ling,
e
Edmond
Gravel,
*a
Sébastien
Mériaux
*b
and
Eric
Doris
*a
‡a
Erwan
Selingue,
b
Agathe
Belime,
a
Guillaume
Pinna,
d
Wai Li
Ling,
e
Edmond
Gravel,
*a
Sébastien
Mériaux
*b
and
Eric
Doris
*a
Abstract
We describe herein the assembly and in vivo evaluation of a tailor-made micellar carrier system designed for the optimized encapsulation of a superfluorinated MRI probe and further targeting of solid tumors. The in vivo validation was carried out on MC38 tumor-bearing mice which allowed the confirmation of the efficient targeting properties of the nano-carrier, as monitored by 19F-MRI.
- This article is part of the themed collection: 2021 Nanoscale HOT Article Collection
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