Recent progress of 1,1-difunctionalization of olefins

Abstract

Olefins are a very important class of compounds and broadly used in the construction of various synthetic building blocks and practical industrial production. The difunctionalization of olefins provides one of the most powerful methods for the C–C or C–X bond formation with a rapid increase of the molecular complexity and synthetic value economically and effectively. Compared with the vigorous growth and abundant achievements of 1,2-difunctionalization of olefins, 1,1-difunctionalization is a relatively emerging and inadequately exploited research direction, despite being tremendously attractive from synthetic perspectives. In this minireview, we provide a brief overview of the advancements of 1,1-difunctionalization of olefins in the past twenty years, and prospects of future developments.