Water as the reaction medium in organic chemistry: from our worst enemy to our best friend

Margery Cortes-Clerget; Julie Yu; Joseph R. A. Kincaid; Peter Walde; Fabrice Gallou; Bruce H. Lipshutz

doi:10.1039/D0SC06000C

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Water as the reaction medium in organic chemistry: from our worst enemy to our best friend

Margery Cortes-Clerget,

*^a Julie Yu,

^c Joseph R. A. Kincaid,

^c Peter Walde,

^b Fabrice Gallou

^a and Bruce H. Lipshutz

Author affiliations

* Corresponding authors

^a Chemical & Analytical Development, Novartis Pharma AG, 4056 Basel, Switzerland
E-mail: mcortes@chem.uesb.edu

^b Department of Materials, ETH Zurich, Zurich, Switzerland

^c Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA

Abstract

A review presenting water as the logical reaction medium for the future of organic chemistry. A discussion is offered that covers both the “on water” and “in water” phenomena, and how water is playing unique roles in each, specifically with regard to its use in organic synthesis.

This article is part of the themed collection: Most popular 2021 organic chemistry articles, 2021

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Article information

DOI: https://doi.org/10.1039/D0SC06000C
Article type: Review Article
Submitted: 01 Nov 2020
Accepted: 02 Jan 2021
First published: 12 Feb 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry

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Chem. Sci., 2021,12, 4237-4266

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Water as the reaction medium in organic chemistry: from our worst enemy to our best friend

M. Cortes-Clerget, J. Yu, J. R. A. Kincaid, P. Walde, F. Gallou and B. H. Lipshutz, Chem. Sci., 2021, 12, 4237 DOI: 10.1039/D0SC06000C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Water as the reaction medium in organic chemistry: from our worst enemy to our best friend

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Water as the reaction medium in organic chemistry: from our worst enemy to our best friend

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