Unexpected triaxial preferences in some all-syn 1,3,5-trifluorocyclohexanes†
Nawaf Al
Maharik, 
c
David B.
Cordes,
a
Alexandra M. Z.
Slawin,
a
Rodrigo A.
Cormanich
*b
and
David
O'Hagan
*a
c
David B.
Cordes,
a
Alexandra M. Z.
Slawin,
a
Rodrigo A.
Cormanich
*b
and
David
O'Hagan
*a
Abstract
Theory and solution NMR indicate that all-syn 1,3,5-trifluorocyclohexane 5 adopts the expected tri-equatorial conformation, however in the solid state the more polar triaxial conformation is observed. This and the favoured conformations of substituted (Me, OMe, NH(CO)Me, NHBoc) derivatives of 5 are investigated to explore triaxial C–F preferences.
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