Cyclodextrin–monosaccharide interactions in water

Abstract

Stability constants and derived Gibbs energies, enthalpies and entropies of complexation of D-monosaccharides with α- and β-cyclodextrin¶ in water at 298.15 K obtained by titration microcalorimetry are reported. The results show that α-cyclodextrin interacts with D-glucose, D-fructose, D-xylose, D-mannose and D-galactose. No heat was evolved with D-arabinose. However, β-cyclodextrin is able to recognise aldopentoses (D-xylose and D-arabinose) but not aldohexoses. ¹³C NMR studies on these systems are discussed.