Effect of temperature on crystal growth and crystal properties of paracetamol

Abstract

The crystal growth kinetics of paracetamol have been investigated at different temperatures and the crystals obtained have been analysed for their mechanical properties. Variations in the crystal habit and crystal quality can be explained by different growth activation energies for the most important crystallographic faces, {001} and {110}. The magnitude of these energies corresponds to the anisotropy of the intermolecular bonds in the crystal lattice. The crystallization temperature strongly influences the thermodynamic and mechanical properties of paracetamol crystals.