Polyanions and their complexes. Part III. Reactions of heparin, hyaluronic acid, sodium poly(ethylenesulphonate), sodium poly(styrenesulphonate), and sodium carboxymethylcellulose with hydroxyl radicals and hydrated electrons

Abstract

Pulse radiolysis techniques have been used to obtain the rate constants for the reactions of e^–_aq and hydroxyl radicals with heparin, hyaluronic acid, sodium poly(ethylenesulphonate), sodium poly(styrenesulphonate), and sodium carboxymethylcellulose. Comparison of the hydroxyl rate constants of the polyanions with those of the related monomeric repeating units indicates that the nature of the polyanion in solution exerts an important influence on reactivity. With the exception of hyaluronic acid the reactions of e^–_aq with the polyanions are generally slow.