The preparation of nucleoside carbonates

Abstract

The preparation of some di(nucleoside) carbonates by means of a simple transesterification reaction is described. The active 3′-O-βββ-trichloroethoxycarbonyl esters of suitably protected pyrimidine nucleosides were treated with the 5′-monosodio-derivatives of 2′,3′-O-isopropylidene-adenosine, -cytidine, -inosine, -guanosine, and -uridine. The method was extended to the preparation of the tri(nucleoside) dicarbonates, di(thymidinyl) adenosinyl dicarbonate and di(deoxyuridinyl) uridinyl dicarbonate.