Synthetic analogues of polynucleotides. Part VII. Further syntheses of 5′-O-acryloylnucleosides and copolymers of these with other acryloyl compounds

Abstract

The synthesis of the 5′-O-acryloyl esters of cytidine, guanosine, and adenosine, by the action of acrylic anhydride on suitably protected nucleosides, followed by removal of the protecting groups, is described. These esters have been copolymerised with acrylamide to give water-soluble copolymers. Copolymers of 5′-O-acryloylcytidine with 6-O-acryloylgalactose have also been prepared.