Issue 10, 1975

Reduction of 3,5-disubstituted pyridines to dihydropyridines

Abstract

The reduction of pyridine-3,5-dicarboxylates by sodium borohydride to give the corresponding 1,2- and 1,4-dihydropyridines has been investigated, and the compositions of the isomer mixtures produced in various solvents have been determined. New syntheses have been developed for 3,5-disubstituted 1,4-dihydropyridines involving reduction with sodium cyanoborohydride, and for 1,2-dihydropyridine-3,5-dicarboxylates involving reduction with diborane. Details of the previously reported catalytic hydrogenation of pyridines are given.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1975, 929-931

Reduction of 3,5-disubstituted pyridines to dihydropyridines

E. Booker and U. Eisner, J. Chem. Soc., Perkin Trans. 1, 1975, 929 DOI: 10.1039/P19750000929

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements