SCHEDULED MAINTENANCE
The neurotoxin conotoxin G1 from Conus geographus has been synthesised by a solid-phase method using fluorenylmethoxycarbonylamino acids and a polar, poly(dimethylacrylamide)-based support. The two disulphide bridges were formed selectively by differential protection of cysteine residues using S-acetamidomethyl and S-t-butylsulphenyl groups.
E. Atherton, R. C. Sheppard and P. Ward, J. Chem. Soc., Perkin Trans. 1, 1985, 2065 DOI: 10.1039/P19850002065
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