Issue 1, 1989

Biosynthetic studies on pseudomonic acid (mupirocin), a novel antibiotic metabolite of Pseudomonas fluorescens

Abstract

2 H and 18O Isotope shifts observed in the 13C n.m.r. spectra of pseudomonic acid (mupirocin) enriched from [1-13C, 2H3]- and [1-13C, 18O2]-acetates provide information on the mechanisms of formation of the tetrahydropyran and ester functions. The results of incorporation studies with 14C- and 13C2 labelled β-hydroxy-β-methylglutarates do not support previous proposals for its involvement in the biosynthesis of pseudomonic acid.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1989, 207-209

Biosynthetic studies on pseudomonic acid (mupirocin), a novel antibiotic metabolite of Pseudomonas fluorescens

F. M. Martin and T. J. Simpson, J. Chem. Soc., Perkin Trans. 1, 1989, 207 DOI: 10.1039/P19890000207

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