Issue 10, 1990

Free radical reactions in synthesis. Homolysis of alkylcobalt complexes in the presence of radical-trapping agents

Abstract

Irradiations of the alkylcobalt salophen complexes (14), (21), (22), and (23) in the presence of radical-trapping agents, e.g. molecular oxygen, tetramethylpiperidine oxide, nitrogen monoxide, diphenyl disulphide, diphenyl diselenide, methanesulphonyl chloride, bromotrichloromethane, or iodine, leads to oxgen-[e.g., (18), (19), and (25)], nitrogen-[e.g., (27) and (28)], sulphur/selenium-[e.g., (30) and (31)] or halogen-(34) functionalised products. When these radical-trapping methodologies are combined with cobalt-mediated radical cyclisation reactions (Scheme 2) a powerful synthetic procedure, i.e. radical carbon-to-carbon bond formation with simultaneous functionalisation of the product radical centre, becomes available.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1990, 2703-2708

Free radical reactions in synthesis. Homolysis of alkylcobalt complexes in the presence of radical-trapping agents

V. F. Patel and G. Pattenden, J. Chem. Soc., Perkin Trans. 1, 1990, 2703 DOI: 10.1039/P19900002703

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