Structural studies of MM46115, a novel tetronic acid containing macrolide with antiviral and antibacterial activity isolated from Actinomadura pelletieri

Abstract

MM46115, a novel antiviral antibiotic produced by the fermentation of Actinomadura pelletieri IP/729.63, has been shown by spectroscopic studies to have a tetronic acid containing macrolide structure and be a new member of the tetrocarcin and kijanimicin family of antibiotics. The molecule also contains a novel diaminohexopyranose linked to a substituted salicylic acid moiety via an amide bond. Evidence for the proposed structure is presented.