Mycinamicin biosynthesis: isolation and structural elucidation of mycinonic acids, proposed intermediates for formation of mycinamicins. X-Ray molecular structure of p-bromophenacyl 5-hydroxy-4-methylhept-2-enoate

Abstract

Mycinonic acids, proposed intermediates in the biosynthesis of the macrolide antibiotic mycinamicins, were isolated from the culture filtrate of Micromonospora griseorubida and their chemical structures were determined on the basis of their spectroscopic data. Their absolute configurations were confirmed by X-ray diffraction analysis and comparison of their total syntheses. Their possible role in the biosynthesis of mycinamicins is discussed.