Addition of organolithium reagents to α-(trifluoromethyl)styrene: concise synthesis of functionalised gem-difluoroalkenes
Abstract
The treatment of α-(trifluoromethyl)styrene with organolithium reagents results in the selective formation of gem-difluoroalkenes in good-to-excellent yields. This reaction has been applied to the synthesis of 3-gem-difluoro-2-phenylallylic amines and other functionalised gem-difluoroalkenes.