Unusually long open times, determined by planar bilayer conductances studies, for a synthetic tris(macrocycle) that functions as a transmembrane channel in a phospholipid bilayer

Abstract

Two tris(macrocycle)s are shown by bilayer clamp studies to function as cation channels in a phospholipid bilayer; one of the pair of closely related compounds shows unusually long open times compared either to the other tris(macrocycle) or to natural channel-forming proteins.