Issue 3, 2000
From the journal:

Chemical Communications

The oxidation of polychlorinated benzenes by genetically engineered cytochrome P450cam: potential applications in bioremediation

Jonathan P. Jones,a   Ellen J. O’Harea  and  Luet-Lok Wong*a  

* Corresponding authors

a Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, UK
E-mail: luet.wong@chem.ox.ac.uk

Abstract

Polychlorinated aromatic compounds are persistent environmental contaminants; we describe here the redesign and engineering of the haem monooxygenase cytochrome P450cam to oxidise these compounds efficiently to the chlorinated phenols which are readily degraded by many micro-organisms, thus providing a basis for novel systems for biological clean-up of these inert compounds.

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Article information

DOI
https://doi.org/10.1039/A909536E
Article type
Communication
Submitted
02 Dec 1999
Accepted
06 Jan 2000
First published
31 Jan 2000

Chem. Commun., 2000, 247-248

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The oxidation of polychlorinated benzenes by genetically engineered cytochrome P450cam: potential applications in bioremediation

J. P. Jones, E. J. O’Hare and L. Wong, Chem. Commun., 2000, 247 DOI: 10.1039/A909536E

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