Issue 23, 2000
From the journal:

Chemical Communications

A pH sensitive fluorescent cyanine dye for biological applications

Mark S. Briggs,a   D. Dougal Burns,a   Michael E. Cooper*a  and  Susan J. Gregorya  

* Corresponding authors

a Drug Discovery, Amersham Pharmacia Biotech, Forest Farm, Whitchurch, Cardiff, UK
E-mail: michael.cooper@eu.apbiotech.com

Abstract

A pentamethine cyanine dye has been synthesised that is fluorescent when protonated, becoming non-fluorescent upon proton abstraction. The probe has a pKa of 7.5, with observable changes in the fluorescent emission properties across a pH range of 6.0–8.0, therefore providing a useful probe for studying pH in biological media.

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Article information

DOI
https://doi.org/10.1039/B007108K
Article type
Communication
Submitted
01 Sep 2000
Accepted
10 Oct 2000
First published
09 Nov 2000

Chem. Commun., 2000, 2323-2324

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A pH sensitive fluorescent cyanine dye for biological applications

M. S. Briggs, D. D. Burns, M. E. Cooper and S. J. Gregory, Chem. Commun., 2000, 2323 DOI: 10.1039/B007108K

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