Issue 8, 2002

Synthesis and biological evaluation of a PtdIns(4,5)P2 and a phosphatidic acid affinity matrix

Abstract

Analogues of dipalmitoyl phosphatidic acid (PA), dilauroyl PA and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] were synthesised and immobilised onto a solid support, Affi-Gel 10. Using them as affinity matrices, a number of known proteins as well as a set of novel proteins were found to bind specifically to PA.

Graphical abstract: Synthesis and biological evaluation of a PtdIns(4,5)P2 and a phosphatidic acid affinity matrix

Article information

Article type
Paper
Submitted
18 Jan 2002
Accepted
14 Feb 2002
First published
15 Mar 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1067-1075

Synthesis and biological evaluation of a PtdIns(4,5)P2 and a phosphatidic acid affinity matrix

Z. Lim, J. W. Thuring, A. B. Holmes, M. Manifava and N. T. Ktistakis, J. Chem. Soc., Perkin Trans. 1, 2002, 1067 DOI: 10.1039/B200585A

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