Issue 3, 2003
From the journal:

New Journal of Chemistry

Three-component coupling reactions in ionic liquids: a facile synthesis of α-aminonitriles

Jhillu S. Yadav,*a   Basi. V. S. Reddy,a   B. Eshwaraiah,a   Mende. Srinivasa  and  P. Vishnumurthya  

* Corresponding authors

a Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India
E-mail: yadav@iict.ap.nic.in
Fax: 91-40-7160512

Abstract

Aryl imines, derived in situ from aldehydes and amines, smoothly undergo addition with trimethylsilyl cyanide in 1-butyl-3-methylimidazolium tetrafluoroborate or 1-butyl-3-methylimidazolium hexafluorophosphate ionic liquids under mild and neutral reaction conditions to afford the corresponding α-aminonitriles in excellent yields. The ionic liquids can be recycled in five to six runs without any apparent loss of activity.

Graphical abstract: Three-component coupling reactions in ionic liquids: a facile synthesis of α-aminonitriles

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Article information

DOI
https://doi.org/10.1039/B208844B
Article type
Letter
Submitted
09 Sep 2002
Accepted
10 Dec 2002
First published
14 Jan 2003

New J. Chem., 2003,27, 462-465

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Three-component coupling reactions in ionic liquids: a facile synthesis of α-aminonitriles

J. S. Yadav, Basi. V. S. Reddy, B. Eshwaraiah, Mende. Srinivas and P. Vishnumurthy, New J. Chem., 2003, 27, 462 DOI: 10.1039/B208844B

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