Issue 8, 2003

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

Abstract

The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with “reversed” protonation-states for nucleophile and acid–base.

Graphical abstract: A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

Supplementary files

Article information

Article type
Communication
Submitted
17 Feb 2003
Accepted
05 Mar 2003
First published
20 Mar 2003

Chem. Commun., 2003, 944-945

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

T. Gloster, S. J. Williams, C. A. Tarling, S. Roberts, C. Dupont, P. Jodoin, F. Shareck, S. G. Withers and G. J. Davies, Chem. Commun., 2003, 944 DOI: 10.1039/B301829F

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