Direct production of ivermectin-like drugs after domain exchange in the avermectinpolyketide synthase of Streptomyces avermitilis ATCC31272
Abstract
* Corresponding authors
a Biotica Technology Limited, 181A Huntingdon Road, Cambridge, UK
b
Cambridge Centre for Molecular Recognition and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK
E-mail:
pfl10@mole.bio.cam.ac.uk
c Cambridge Centre for Molecular Recognition and Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
d Bioprocess R & D, Pfizer Global Research & Development, Groton Labs., Eastern Point Road, Groton, CT 06340, USA
e BASILEA Pharmaceutica Ltd., Basel, Switzerland
f Bayer AG, 42096 Wuppertal, Germany
g Unilever Bestfoods UK, London Road, Purfleet, Essex, UK
S. Gaisser, L. Kellenberger, A. L. Kaja, A. J. Weston, R. E. Lill, G. Wirtz, S. G. Kendrew, L. Low, R. M. Sheridan, B. Wilkinson, I. S. Galloway, K. Stutzman-Engwall, H. A. I. McArthur, J. Staunton and P. F. Leadlay, Org. Biomol. Chem., 2003, 1, 2840 DOI: 10.1039/B304022D
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