Issue 18, 2003
From the journal:

Chemical Communications

Conjugation of poor inhibitors with surface binding groups: a strategy to improve inhibition†

Bidhan C. Roy,a   Ryan Hegge,a   Theresa Rosendahl,a   Xiao Jia,a   Rachael Lareau,a   Sanku Mallik*a  and  D. K. Srivastavaa  

* Corresponding authors

a Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota, USA
E-mail: Sanku.Mallik@ndsu.nodak.edu
Fax: 701-231-8831
Tel: 701-231-8829

Abstract

Conjugation of surface binding groups with inhibitors for carbonic anhydrase leads to the conversion of weak inhibitors to strong inhibitors.

Graphical abstract: Conjugation of poor inhibitors with surface binding groups: a strategy to improve inhibition

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Article information

DOI
https://doi.org/10.1039/B305179J
Article type
Communication
Submitted
08 May 2003
Accepted
25 Jul 2003
First published
04 Aug 2003

Chem. Commun., 2003, 2328-2329

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Conjugation of poor inhibitors with surface binding groups: a strategy to improve inhibition

B. C. Roy, R. Hegge, T. Rosendahl, X. Jia, R. Lareau, S. Mallik and D. K. Srivastava, Chem. Commun., 2003, 2328 DOI: 10.1039/B305179J

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