Issue 22, 2003

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketidetoxinmycolactone by a clinical isolate of Mycobacterium ulcerans

Abstract

LC-MSn analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.

Graphical abstract: Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2003
Accepted
05 Aug 2003
First published
20 Oct 2003

Chem. Commun., 2003, 2822-2823

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

H. Hong, P. J. Gates, J. Staunton, T. Stinear, S. T. Cole, P. F. Leadlay and J. B. Spencer, Chem. Commun., 2003, 2822 DOI: 10.1039/B308163J

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