Issue 14, 2004

Magnetic nanoparticle design for medical diagnosis and therapy

Abstract

Magnetic nanoparticles have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia. This review examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint (e.g. relaxivity for MRI and specific absorption rate for hyperthermia), the factors affecting their biodistribution (e.g. size, surface hydrophobic/hydrophilic balance, etc.) and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells.

Graphical abstract: Magnetic nanoparticle design for medical diagnosis and therapy

Article information

Article type
Feature Article
Submitted
10 Feb 2004
Accepted
19 Apr 2004
First published
02 Jun 2004

J. Mater. Chem., 2004,14, 2161-2175

Magnetic nanoparticle design for medical diagnosis and therapy

S. Mornet, S. Vasseur, F. Grasset and E. Duguet, J. Mater. Chem., 2004, 14, 2161 DOI: 10.1039/B402025A

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