Issue 4, 2004

Poly(dimethylsiloxane) microchip: microchannel with integrated open electrospray tip

Abstract

A polymer microchip with an open tip for electrospray mass spectrometry is presented. The tip consists of a groove with parallel walls where a droplet can form at the end surface. A lid covers the whole chip except at the microchannel tip, which is left open. Poly(dimethylsiloxane) (PDMS) microchips were cast using a nickel mould which in turn was replicated from a dry etched silicon wafer. Tips with microchannel widths of around 50 µm could easily be replicated. Since the tip had no cover, the assembly of microchip and cover was simplified. A total ion current variation of 5% during 300 s was achieved for a 1 µM myoglobin solution. The non-complex design of the cover makes it suitable for versatile tests of chip prototypes. The nickel mould was found to be useful for PDMS microstructure fabrication. Also, such a robust mould allows casting electrospray tips in more rigid thermoset materials.

Article information

Article type
Paper
Submitted
18 Feb 2004
Accepted
19 Apr 2004
First published
14 May 2004

Lab Chip, 2004,4, 322-327

Poly(dimethylsiloxane) microchip: microchannel with integrated open electrospray tip

M. Svedberg, M. Veszelei, J. Axelsson, M. Vangbo and F. Nikolajeff, Lab Chip, 2004, 4, 322 DOI: 10.1039/B402490G

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