Issue 16, 2004
From the journal:

Chemical Communications

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A†

Tracey M. Gloster,a   Spencer J. Williams,b   Shirley Roberts,a   Chris A. Tarling,c   Jacqueline Wicki,c   Stephen G. Withersc  and  Gideon J. Davies*a  

* Corresponding authors

a Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, UK
E-mail: davies@ysbl.york.ac.uk

b School of Chemistry, University of Melbourne, Parkville, Australia

c Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, Canada

Abstract

The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted 4C1 chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pKa changes of the enzyme's catalytic machinery upon binding.

Graphical abstract: Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

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Article information

DOI
https://doi.org/10.1039/B405152A
Article type
Communication
Submitted
07 Apr 2004
Accepted
04 Jun 2004
First published
23 Jul 2004

Chem. Commun., 2004, 1794-1795

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Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

T. M. Gloster, S. J. Williams, S. Roberts, C. A. Tarling, J. Wicki, S. G. Withers and G. J. Davies, Chem. Commun., 2004, 1794 DOI: 10.1039/B405152A

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