Superparamagnetic gadonanotubes are high-performance MRI contrast agents

Balaji Sitharaman; Kyle R. Kissell; Keith B. Hartman; Lesa A. Tran; Andrei Baikalov; Irene Rusakova; Yanyi Sun; Htet A. Khant; Steven J. Ludtke; Wah Chiu; Sabrina Laus; Éva Tóth; Lothar Helm; André E. Merbach; Lon J. Wilson

doi:10.1039/B504435A

Superparamagnetic gadonanotubes are high-performance MRI contrast agents†

Balaji Sitharaman,^a Kyle R. Kissell,^a Keith B. Hartman,^a Lesa A. Tran,^a Andrei Baikalov,^b Irene Rusakova,^b Yanyi Sun,^b Htet A. Khant,^c Steven J. Ludtke,^c Wah Chiu,^c Sabrina Laus,^d Éva Tóth,^d Lothar Helm,^d André E. Merbach^d and Lon J. Wilson*^a

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^a Department of Chemistry, the Center for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology MS 60, Rice University, Houston, Texas, USA
E-mail: durango@rice.edu
Fax: 713-348-5155
Tel: 713-348-3268

^b The Texas Center for Superconductivity, University of Houston, Texas, USA

^c Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA

^d Laboratoire de Chimie Inorganique et Bioinorganique, Ecole Polytechnique Fédérale de Lausanne, EPFL-BCH, Lausanne, Switzerland

Abstract

We report the nanoscale loading and confinement of aquated Gd³⁺_n-ion clusters within ultra-short single-walled carbon nanotubes (US-tubes); these Gd³⁺_n@US-tube species are linear superparamagnetic molecular magnets with Magnetic Resonance Imaging (MRI) efficacies 40 to 90 times larger than any Gd³⁺-based contrast agent (CA) in current clinical use.

Chemical Communications

Superparamagnetic gadonanotubes are high-performance MRI contrast agents†

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Superparamagnetic gadonanotubes are high-performance MRI contrast agents

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