Issue 36, 2005
From the journal:

Chemical Communications

Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry†

Dirk T. S. Rijkers,a   G. Wilma van Esse,a   Remco Merkx,a   Arwin J. Brouwer,a   Hans J. F. Jacobs,a   Roland J. Pietersa  and  Rob M. J. Liskamp*a  

* Corresponding authors

a Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, PO Box 80082, Utrecht, The Netherlands
E-mail: R.M.J.Liskamp@pharm.uu.nl
Fax: +31 30 253 6655
Tel: +31 30 253 7396/7307

Abstract

Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.

Graphical abstract: Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

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Article information

DOI
https://doi.org/10.1039/B507975F
Article type
Communication
Submitted
06 Jun 2005
Accepted
11 Jul 2005
First published
19 Aug 2005

Chem. Commun., 2005, 4581-4583

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Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

D. T. S. Rijkers, G. W. van Esse, R. Merkx, A. J. Brouwer, H. J. F. Jacobs, R. J. Pieters and R. M. J. Liskamp, Chem. Commun., 2005, 4581 DOI: 10.1039/B507975F

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