Issue 10, 2006

High-pressure studies of pharmaceutical compounds and energetic materials

Abstract

The effects of high pressure on pharmaceutical compounds and energetic materials can have important implications for both the properties and performance of these important classes of material. Pharmaceutical compounds are frequently subjected to pressure during processing and formulation, causing interconversion between solid forms that may affect properties such as solubility and bio-availability. Energetic materials experience extremes of both pressure and temperature under conditions of detonation and deflagration, causing changes in properties such as sensitivity to shock and chemical reactivity. This tutorial review outlines the various methods used to study these materials at high pressure, describes how pressure can be used to explore polymorphism, and provides examples of compounds that have been studied at high pressure.

Graphical abstract: High-pressure studies of pharmaceutical compounds and energetic materials

Article information

Article type
Tutorial Review
Submitted
10 Jul 2006
First published
08 Aug 2006

Chem. Soc. Rev., 2006,35, 932-942

High-pressure studies of pharmaceutical compounds and energetic materials

F. P. A. Fabbiani and C. R. Pulham, Chem. Soc. Rev., 2006, 35, 932 DOI: 10.1039/B517780B

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