Issue 42, 2006
From the journal:

Chemical Communications

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor†

Bhagavathy Shanmugasundaram,a   Aleksandra W. Debowski,b   Rebecca J. Dennis,c   Gideon J. Davies,c   David J. Vocadlob  and  Andrea Vasella*a  

* Corresponding authors

a Laboratorium für Organische Chemie, HCI H 317, ETH Zürich, CH-8093 Zürich, Switzerland
E-mail: vasella@org.chem.ethz.ch
Fax: +41 1 632 11 36
Tel: +41 1 632 45 16

b Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, Canada
E-mail: dvocadlo@sfu.ca
Fax: +1 604 291 3765
Tel: +1 604 291 3530

c Department of Chemistry, The University of York, Heslington, York, UK
E-mail: davies@ysbl.york.ac.uk
Fax: +44 1904 328266
Tel: +44 1904 328260

Abstract

Synthesis of a PUGNAc–imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

Graphical abstract: Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

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Article information

DOI
https://doi.org/10.1039/B612154C
Article type
Communication
Submitted
23 Aug 2006
Accepted
11 Sep 2006
First published
29 Sep 2006

Chem. Commun., 2006, 4372-4374

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Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

B. Shanmugasundaram, A. W. Debowski, R. J. Dennis, G. J. Davies, D. J. Vocadlo and A. Vasella, Chem. Commun., 2006, 4372 DOI: 10.1039/B612154C

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