Issue 5, 2007
From the journal:

New Journal of Chemistry

Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins†‡

Steven Fletchera  and  Andrew D. Hamilton*a  

* Corresponding authors

a Department of Chemistry, 225, Prospect Street, Yale University, New Haven, USA
E-mail: andrew.hamilton@yale.edu
Fax: +1-203-432-5570
Tel: +1-203-432-3221

Abstract

A synthetic, copper porphyrin unwinds the α-helical domains of the heme proteins hemoglobin, myoglobin and cytochrome c, thereby catalysing trypsin-mediated proteolysis.

Graphical abstract: Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins

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Article information

DOI
https://doi.org/10.1039/B700123A
Article type
Letter
Submitted
04 Jan 2007
Accepted
13 Mar 2007
First published
03 Apr 2007

New J. Chem., 2007,31, 623-627

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Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins

S. Fletcher and A. D. Hamilton, New J. Chem., 2007, 31, 623 DOI: 10.1039/B700123A

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