Issue 12, 2008
From the journal:

Soft Matter

Production and performance of biomaterials containing RGDpeptides

Lynne Perlin,a   Sheila MacNeilb  and  Stephen Rimmer*a  

* Corresponding authors

a Chemistry Department, University of Sheffield, Sheffield, South Yorkshire, UK

b Department of Engineering Materials, The Kroto Institute, University of Sheffield, Sheffield, South Yorkshire, UK

Abstract

The arginine-glycine-aspartic acid (RGD) sequence binds to key cell membrane structures within the integrin family. These sequences are found on several extracellular proteins that have roles in cell adhesion. Therefore, it is not surprising that with the advent of the field of tissue engineering a large amount of work has been carried out on materials functionalised with a wide variety of RGD-containing peptides. In this review we provide an overview of the field to 2007 and we include both synthesis and design strategies required to produce useful RGD functional materials.

Graphical abstract: Production and performance of biomaterials containing RGD peptides

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Article information

DOI
https://doi.org/10.1039/B801646A
Article type
Review Article
Submitted
30 Jan 2008
Accepted
16 Jul 2008
First published
19 Sep 2008

Soft Matter, 2008,4, 2331-2349

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Production and performance of biomaterials containing RGD peptides

L. Perlin, S. MacNeil and S. Rimmer, Soft Matter, 2008, 4, 2331 DOI: 10.1039/B801646A

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