Issue 11, 2008

Epigenetic remodeling of the fungal secondary metabolome

Abstract

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

Graphical abstract: Epigenetic remodeling of the fungal secondary metabolome

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2008
Accepted
04 Apr 2008
First published
14 Apr 2008

Org. Biomol. Chem., 2008,6, 1895-1897

Epigenetic remodeling of the fungal secondary metabolome

R. B. Williams, J. C. Henrikson, A. R. Hoover, A. E. Lee and R. H. Cichewicz, Org. Biomol. Chem., 2008, 6, 1895 DOI: 10.1039/B804701D

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