Issue 9, 2008
From the journal:

CrystEngComm

Co-crystallisation at high pressure—an additional tool for the preparation and study of co-crystals†

Iain D. H. Oswald*a  and  Colin R. Pulhama  

* Corresponding authors

a School of Chemistry and the Centre for Science at Extreme Conditions, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK
E-mail: iain.oswald@ed.ac.uk
Fax: +44 (0)131 650 4743
Tel: +44 (0)131 651 7222

Abstract

Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2 : 1 co-crystal of paracetamol : piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2 : 1 co-crystal of paracetamol : piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.

Graphical abstract: Co-crystallisation at high pressure—an additional tool for the preparation and study of co-crystals

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Article information

DOI
https://doi.org/10.1039/B805591B
Article type
Communication
Submitted
02 Apr 2008
Accepted
14 May 2008
First published
04 Jun 2008

CrystEngComm, 2008,10, 1114-1116

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Co-crystallisation at high pressure—an additional tool for the preparation and study of co-crystals

I. D. H. Oswald and C. R. Pulham, CrystEngComm, 2008, 10, 1114 DOI: 10.1039/B805591B

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