Issue 44, 2008
From the journal:

Chemical Communications

Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid†

Shuho Tanimoto,a   Satoshi Sakai,a   Shuichi Matsumura,a   Daisuke Takahashia  and  Kazunobu Toshima*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81-45-566-1576
Tel: +81-45-566-1576

Abstract

A designed fullerene-sugar hybrid effectively and selectively degraded the target protein, HIV-1 protease, which has high affinity for the fullerene moiety; degradation was achieved using long-wavelength UV or visible photo-irradiation, in the absence of any additives and under neutral conditions.

Graphical abstract: Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

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Article information

DOI
https://doi.org/10.1039/B811726H
Article type
Communication
Submitted
09 Jul 2008
Accepted
22 Aug 2008
First published
02 Oct 2008

Chem. Commun., 2008, 5767-5769

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Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

S. Tanimoto, S. Sakai, S. Matsumura, D. Takahashi and K. Toshima, Chem. Commun., 2008, 5767 DOI: 10.1039/B811726H

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