Issue 2, 2009
From the journal:

Organic & Biomolecular Chemistry

Synthesis of unsymmetrical ketonesvia simple C–H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates†

Richard J. Fitzmaurice,a   Jenna M. Aherna  and  Stephen Caddick*a  

* Corresponding authors

a Department of Chemistry, University College London, London, UK
E-mail: s.caddick@ucl.ac.uk
Fax: +44 (0)20 7679 4603
Tel: +44 (0)20 7679 7482

Abstract

A new and simple protocol for the direct functionalisation of aldehydes with concomitant conversion into ketones via C–C bond formation has been developed. The reaction effectively enables the direct C–H activation of an aldehyde by mixing of an aldehyde and a vinyl sulfonate under aerobic conditions or using hydrogen peroxide as a sub-stoichiometric reagent.

Graphical abstract: Synthesis of unsymmetrical ketones via simple C–H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

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Article information

DOI
https://doi.org/10.1039/B819235A
Article type
Communication
Submitted
29 Oct 2008
Accepted
13 Nov 2008
First published
26 Nov 2008

Org. Biomol. Chem., 2009,7, 235-237

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Synthesis of unsymmetrical ketones via simple C–H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

R. J. Fitzmaurice, J. M. Ahern and S. Caddick, Org. Biomol. Chem., 2009, 7, 235 DOI: 10.1039/B819235A

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