Issue 18, 2009
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological evaluation of a novel cardiolipin affinity matrix†

Melloney K. Johns,a   Meng-Xin Yin,b   Stuart J. Conway,ac   Diane E. J. E. Robinson,b   Leon S.-M. Wong,b   Rebecca Bamert,de   Richard E. H. Wettenhalle  and  Andrew B. Holmes*b  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

b School of Chemistry, Bio21 Institute, Building 102, 30 Flemington Road, University of Melbourne, Parkville, VIC, Australia

c Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK

d Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia

e Bio21 Institute, Building 102, 30 Flemington Road, University of Melbourne, Parkville, VIC, Australia

Abstract

Cardiolipin (1) is a dimeric phospholipid found in the mitochondrial membranes of both plants and animals. In order to understand better its role, we report the preparation of an immobilised analogue (2) using phosphoramidite chemistry; the probe has been used successfully to bind a recombinant protein containing a cardiolipin-binding domain.

Graphical abstract: Synthesis and biological evaluation of a novel cardiolipin affinity matrix

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Article information

DOI
https://doi.org/10.1039/B909306K
Article type
Paper
Submitted
12 May 2009
Accepted
09 Jun 2009
First published
14 Jul 2009

Org. Biomol. Chem., 2009,7, 3691-3697

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Synthesis and biological evaluation of a novel cardiolipin affinity matrix

M. K. Johns, M. Yin, S. J. Conway, D. E. J. E. Robinson, L. S.-M. Wong, R. Bamert, R. E. H. Wettenhall and A. B. Holmes, Org. Biomol. Chem., 2009, 7, 3691 DOI: 10.1039/B909306K

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