Issue 22, 2010
From the journal:

Organic & Biomolecular Chemistry

Investigating possible changes in protein structure during dendrimer–protein binding†

F. Chiba,a   G. Manna  and  L. J. Twyman*a  

* Corresponding authors

a Chemistry Department, University of Sheffield, Sheffield, UK
E-mail: l.j.twyman@Sheffield.ac.uk
Fax: +44 (0)114 2229346
Tel: +44 (0)114 2229560

Abstract

Building on our previous results that revealed a sized based mechanism for dendrimer/protein binding, the mechanism of complexation is further probed using CD spectroscopy; the results demonstrate that dendrimer/protein binding is not accompanied by changes in the protein's structure and that binding takes place on the interfacial area/active site entrance.

Graphical abstract: Investigating possible changes in protein structure during dendrimer–protein binding

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Article information

DOI
https://doi.org/10.1039/C0OB00041H
Article type
Communication
Submitted
23 Apr 2010
Accepted
02 Aug 2010
First published
23 Sep 2010

Org. Biomol. Chem., 2010,8, 5056-5058

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Investigating possible changes in protein structure during dendrimer–protein binding

F. Chiba, G. Mann and L. J. Twyman, Org. Biomol. Chem., 2010, 8, 5056 DOI: 10.1039/C0OB00041H

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