Issue 7, 2017
From the journal:

Organic & Biomolecular Chemistry

Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy†

Masafumi Ueda,a   Kengo Ashizawa,a   Kouta Sugikawa,a   Kazuya Koumoto,b   Takeshi Nagasakic  and  Atsushi Ikeda ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1-4-1 Higashi, Hiroshima 739-8527, Japan
E-mail: aikeda@hiroshima-u.ac.jp
Fax: +81-82-424-7734
Tel: +81-82-424-7734

b Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe, Japan

c Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan

Abstract

Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum ratio of boron atoms in liposomal boron carriers.

Graphical abstract: Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy

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Article information

DOI
https://doi.org/10.1039/C6OB02142E
Article type
Communication
Submitted
03 Oct 2016
Accepted
28 Oct 2016
First published
28 Oct 2016

Org. Biomol. Chem., 2017,15, 1565-1569

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Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy

M. Ueda, K. Ashizawa, K. Sugikawa, K. Koumoto, T. Nagasaki and A. Ikeda, Org. Biomol. Chem., 2017, 15, 1565 DOI: 10.1039/C6OB02142E

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