Download MendeleyCrystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Bond, C.S., Zhang, Y., Berriman, M., Cunningham, M.L., Fairlamb, A.H., Hunter, W.N.(1999) Structure 7: 81-89
- PubMed: 10368274
- DOI: https://doi.org/10.1016/s0969-2126(99)80011-2
- Primary Citation of Related Structures:
1BZL - PubMed Abstract:
Trypanothione reductase (TR) helps to maintain an intracellular reducing environment in trypanosomatids, a group of protozoan parasites that afflict humans and livestock in tropical areas. This protective function is achieved via reduction of polyamine-glutathione conjugates, in particular trypanothione. TR has been validated as a chemotherapeutic target by molecular genetics methods. To assist the development of new therapeutics, we have characterised the structure of TR from the pathogen Trypanosoma cruzi complexed with the substrate trypanothione and have used the structure to guide database searches and molecular modelling studies.
Organizational Affiliation:
Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK Department of Biochemistry University of Sydney Sydney NSW 2006 Australia.
