Download MendeleyStructure of a CXC chemokine-receptor fragment in complex with interleukin-8.
Skelton, N.J., Quan, C., Reilly, D., Lowman, H.(1999) Structure 7: 157-168
- PubMed: 10368283
- DOI: https://doi.org/10.1016/S0969-2126(99)80022-7
- Primary Citation of Related Structures:
1ILP, 1ILQ - PubMed Abstract:
Interactions between CXC chemokines (e.g. interleukin-8, IL-8) and their receptors (e.g. CXCR-1) have a key role in host defense and disease by attracting and upregulating neutrophils to sites of inflammation. The transmembrane nature of the receptor impedes structure-based understanding of ligand interactions. Linear peptides based on the N-terminal, extracellular portion of the receptor CXCR-1 do bind to IL-8, however, and inhibit the binding of IL-8 to the full-length receptor.
Organizational Affiliation:
Department of Protein Engineering Genentech, Inc. South San Francisco, CA 94080, USA. skelly@gene.com
