1O8A
Crystal Structure of Human Angiotensin Converting Enzyme (Native).
- PDB DOI: https://doi.org/10.2210/pdb1O8A/pdb
- Classification: METALLOPROTEASE
- Organism(s): Homo sapiens
- Expression System: Cricetulus griseus
- Mutation(s): No 
- Deposited: 2002-11-26 Released: 2003-02-07 
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.220 
- R-Value Work: 0.180 
- R-Value Observed: 0.180 
wwPDB Validation   3D Report Full Report
This is version 2.2 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ANGIOTENSIN CONVERTING ENZYME | 589 | Homo sapiens | Mutation(s): 0  EC: 3.4.15.1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P12821 (Homo sapiens) Explore P12821  Go to UniProtKB:  P12821 | |||||
PHAROS:  P12821 GTEx:  ENSG00000159640  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P12821 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
Ligands 5 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG Query on NAG | B [auth A] C [auth A] D [auth A] E [auth A] F [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N | |||
NXA Query on NXA | J [auth A] | N-CARBOXYALANINE C4 H7 N O4 JCVPWRQVQNVNGU-REOHCLBHSA-N | |||
ZN Query on ZN | I [auth A] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N | |||
ACT Query on ACT | H [auth A] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M | |||
CL Query on CL | K [auth A], L [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.220 
- R-Value Work: 0.180 
- R-Value Observed: 0.180 
- Space Group: P 21 21 21
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 56.62 | α = 90 |
b = 85.06 | β = 90 |
c = 133.79 | γ = 90 |
Software Name | Purpose |
---|---|
CNS | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
CNS | phasing |
Entry History 
Deposition Data
- Released Date: 2003-02-07  Deposition Author(s): Natesh, R., Schwager, S.L.U., Sturrock, E.D., Acharya, K.R.
Revision History (Full details and data files)
- Version 1.0: 2003-02-07
Type: Initial release - Version 1.1: 2011-05-08
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 2.0: 2018-07-11
Changes: Advisory, Atomic model, Data collection, Database references, Derived calculations, Non-polymer description, Structure summary - Version 2.1: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Derived calculations, Structure summary - Version 2.2: 2023-12-13
Changes: Data collection, Database references, Refinement description, Structure summary