Download MendeleySolution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.
Fahrner, R.L., Dieckmann, T., Harwig, S.S., Lehrer, R.I., Eisenberg, D., Feigon, J.(1996) Chem Biol 3: 543-550
- PubMed: 8807886
- DOI: https://doi.org/10.1016/s1074-5521(96)90145-3
- Primary Citation of Related Structures:
1PG1 - PubMed Abstract:
The protegrins are a family of arginine- and cysteine-rich cationic peptides found in porcine leukocytes that exhibit a broad range of antimicrobial and antiviral activities. They are composed of 16-18 amino-acid residues including four cysteines, which form two disulfide linkages. To begin to understand the mechanism of action of these peptides, we set out to determine the structure of protegrin-1 (PG-1).
Organizational Affiliation:
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA. feigon@ewald.mbi.ucla.edu
